Welcome to the gene prioritisation tool.
Currently, it is a work in progress. However the gene expression-based module is active.
Please report any bugs or post comments here
141 Mouse and Human Tissues
9972862 Gene Expression Values
In attempts to determine the genetic causes of human disease researchers often deal with a substantial quantity of candidate genes. Linkage studies can point to a genomic region containing hundreds of genes, while the high-throughput sequencing approach will identify a multitude of non-synonymous, potentially pathogenic genetic variants.
Systematic experimental verification of each such candidate gene is infeasible due to time and cost implications. A researcher will therefore have to decide which genes are worth investigating further. This decision can be made by manually trawling through vast amounts of literature and/or public databases and selecting the likeliest candidates based on various factors. However, such approach is time consuming and prone to human biases and errors.
Computational gene prioritisation presents itself as a solution to this problem, systematically analysing candidate genes based on various criteria and sorting the candidates from the most likely gene to be disease causative to the least in a fraction of the time it would take a researcher to perform such queries manually. Here, candidate genes are prioritised using baseline gene expression data for normal human and mouse tissues, working under a hypothesis that expression patterns of a disease gene are different in tissues affected by the disease than in those not exhibiting the phenotype.
04/04/14 Small UI changes; FAQ made available; Speed optimisations; Minor bug fixes.
21/03/14 Mouse tissue queries implemented. UI redesigned;
14/03/14 Expression module for human tissues and cell lines active.